Structure-informed microbial population genetics elucidate selective pressures that shape protein evolution.

Although highly significant (one-sided Pearson P = 9 × 10 −12 for RSA and P = 2 × 10 −4 for DTL), the magnitude that ns-polymorphism distributions shift with respect to DTL and RSA was subtle: Across samples, the mean DTL of ns-polymorphism varied by less than 1 Å, and the mean RSA varied between 0.34 and 0.38.

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