Clinicopathological analysis of GLUT-1, GLS1, and GLS2 expression in breast cancer tissues from Jordanian patients.

Sci Rep · 2025 · PMC12489116 · PMID 41034261

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0530

boldest claim

The sentences

highly significantP <.01actually significant

Both GLS1 and GLS2 exhibited markedly higher expression in cancer tissues with a highly significant difference ( P <.01), highlighting alterations in glutamine utilization in tumor cells In addition, GLUT-1, showed significantly elevated levels in cancer tissues ( P ≤.01), indicating an increase in glucose uptake by tumor cells.

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marginal significancep =.053so close (0.05 < p ≤ 0.1)

GLS2 expression exhibited a trend toward higher levels in the Basal subtype, with marginal significance ( p =.053), suggesting a potential subtype-specific role that may warrant further investigation (Fig. 5 b and c).

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