Interestingly, synthesis of indazole-type N-glycosides by means of the BEPT protocol exhibits an evident trend that furanosyl donors give 1-N-glycosides while pyranosyl donors furnish 2-N-glycosides as determined by C3 chemical shift (130 ppm for N1- while 120 ppm N2-products) (see Supplementary Information ), exquisitely complementing Taylor’s method 29 .
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Direct and efficient synthesis of nucleosides through the ortho-(tert-butylethynyl)phenyl thioglycosides (BEPTs) protocol.
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