However, for PF@HCZ, the collagen-1 content remained similar to the pretreatment level, while the levels of α -SMA even exhibiting a decreasing trend ( Fig. 4 D), which demonstrated that the treatment with PF@HCZ significantly reduced the activating effect of exosomes secreted by aHSCs on qHSCs.
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Intercellular communication interference through energy metabolism-related exosome secretion inhibition for liver fibrosis treatment.
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