miR-125b-5p and miR-145a-5p modulation drives functional enhancement of Wharton's Jelly-MSCs derived small extracellular vesicles in response to hypoxia preconditioning.

Cell Commun Signal · 2025 · PMC12492563 · PMID 41039519

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closest p · 0.0× alpha

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highly significantp < 0.0001actually significant

This assay demonstrated a highly significant reduction ( p < 0.0001) in gene expression for both IL-6R (~ 70%) and TGFβ2 (~ 86%) upon respective binding of miR-125b-5p and miR-145a-5p.

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