SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesis.

5D ) however these differences were highly significant on digital quantification for PAX8 IHC expression (Fig. 5E , F ), indicating that both SFPQ-TFE3 and PRCC-TFE3 expression drives varying degrees of renal lineage factor loss in the murine kidney.

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While Torin1 treatment did not significantly impact renal tumor burden in female STP mice, there was a small and borderline significant reduction in tumor area in male STP kidneys, which show a lower tumor burden overall to their female counterparts (Supplementary Fig. 11C ).

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