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A new direction for adjunctive therapy of difficult-to-treat depression: examining the role of orexin receptor antagonists.

Eur Arch Psychiatry Clin Neurosci · 2025 · PMC12500732 · PMID 40434499

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an overall trendno p-value reported
It is noteworthy that the only study to assess CSF across the 24-h period found an overall trend toward elevated Orexin levels and a significant flattening of the amplitude of diurnal variation [ 29 ].

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