Modulation of stress granules by lobeline increases cell death in hypoxia and impacts the ability of glioblastoma cells to secrete extracellular vesicles.

Synergistic cell death was also observed in U3085 cells, with a significant increase in early and late apoptosis/necrosis 24 h post-hypoxia in cells that had received 50 μM lobeline with a trend towards significance at higher concentrations (100 μM) (Q1–Q3, Fig. 5 ).

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