Targeting mitochondrial translation and OXPHOS in high-grade serous ovarian carcinoma eliminates stem-like cells.

Cell Death Dis · 2025 · PMC12501233 · PMID 41053051

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An overall trend of increased OPA1 expression and decreased DRP1 levels was observed in HGSC phenotypes under serum-deprived conditions; with CaOV3 (iE) and A4 (iM) cells being outliers for DRP1 expression, while OVCA420 (E/M) and OVMZ6 (M) were outliers for OPA1 expression (Fig. 5c–i, c–ii ).

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