Differential effects of soluble and plaque amyloid on late-life depression: The moderating role of tau pathology.

J Prev Alzheimers Dis · 2025 · PMC12501351 · PMID 40750516

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hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

marginally significantp = 0.054so close (0.05 < p ≤ 0.1)

As summarized in Supplementary Table S4, the interaction remained statistically significant for the CSDD (β = –18.856, 95 % CI: –36.432 to –1.281, p = 0.035) and HAM-D (β = –17.354, 95 % CI: –33.565 to –1.143, p = 0.036), and marginally significant for the GDS-SV (β = –18.134, 95 % CI: –36.580 to 0.312, p = 0.054).

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an increasing trendno p-value reported

Amyloid beta distribution by tau burden When tau PET SUVR was divided into quartiles, MDS-OAβ levels showed an increasing trend from the 1st to the 3rd quartile, followed by a decrease in the 4th quartile.

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