Experimental Environment Is a Determinant of Gene Methylation and One-Carbon Metabolism in Obese Adult Mice.

Additionally, there was a positive trend between mRNA expression of the gene and methylation of CpG 3 ( p = 0.07, Fig. 3 b).

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Adding MVM to the HF diet also increased methylation at CpG sites and the average methylation level within the Rbp4 gene ( p < 0.05), except for CpG 4 ( p = 0.080) and CpG 6 ( p = 0.061), which showed an increasing trend ( Fig. 6 ).

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