119 High levels of Akkermansia and Methylobacterium in hepatocellular carcinoma tissues were associated with a favorable prognosis, suggesting that Akkermansia and Methylobacterium may be significant prognostic markers for hepatocellular carcinoma. 92 The presence of Methylobacterium within gastric cancer tumors was associated with poor prognosis of cancer patients. 122 In addition, some intra-tumoral microbes, such as Fusobacterium , Pseudoxanthomonas , Streptomyces , Saccharopolyspora , and Bacillus clausii , are associated with the prognosis of pancreatic cancer, 53 , 54 indicating that these microbes may be prognostic biomarkers for pancreatic cancer patients.
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The specific hallmarks, emerging roles, key mechanisms, and clinical applications of intra-tumoral microbiota in human cancers.
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