Transcriptional responses of mouse proximal colon and colonoids during early whipworm infection.

In a previous study, these serine proteases displayed an overall trend of increasing expression levels during in vivo infection stages, from egg to L1 at three hpi, L1 at 24 hpi, and L2 larvae ( 17 ).

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The number of DEGs showed a decreasing trend in as infection progressed in colonoids: 587 DEGs (282 upregulated and 305 downregulated) at two hpi, 99 DEGs (15 upregulated and 84 downregulated) at 24 hpi, and 80 DEGs (26 upregulated and 54 downregulated) at 48 hpi ( Table 1 ).

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