Barely Significant
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Depressive disorders: systematic review of approved psychiatric medications (2009-April 2025) and pipeline phase 3 medications.

BMC Psychiatry · 2025 · PMC12506068 · PMID 41057811

Europe PMCDOI
1
hedged sentence
0.0830
closest p · 1.7× alpha
0.0830
boldest claim

The sentences

a trend towards significanceP = 0.083so close (0.05 < p ≤ 0.1)
The results demonstrated a significant improvement in MADRS total score for the seltorexant 20 mg group compared to placebo at week 3 (least-square means difference: −4.5, 90% CI: −6.96 to −2.07, P = 0.003) and a trend towards significance at week 6 (least-square means difference: −3.1, 90% CI: −6.13 to −0.16, P = 0.083).

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