Epigenetic Clocks as Biomarkers for Bone Aging: Evidence From a Twin Study.

Positive beta coefficients were also seen with borderline significance in the twin pair analysis for the Horvath, IEAA, and Hannum clocks for total hip ( p = 0.052–0.096), for the Hannum clock for femoral neck ( p = 0.063), and for the PhenoAge clock for lumbar spine ( p = 0.099) (Figure 4 ).

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Individual Level Analysis As seen in Figure 2 and File S5 , the Discovery cohort revealed several significant or borderline significant associations to fragility fractures or osteoporosis, with DunedinPoAm and PhenoAge being significant in both diagnostic groups.

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