Topical and transdermal lipid-polymer hybrid nanoparticles (LPN): an integration in advancing dermatological treatments.

Drug Deliv Transl Res · 2025 · PMC12507986 · PMID 40802031

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Furthermore, the in vivo TFL test revealed an increasing trend of local anaesthetic effect duration beginning from free lidocaine (peak effect lasting 10 min), followed by lidocaine-loaded liposomes (peak effect lasting 20 min), and lidocaine-loaded LPN (peak effect lasting 30 min) [ 127 ].

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