Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers.

Though no single pPGS reached the same degree of significance as the gwPGS, interactions were highly significant for multiple pathways, including glycerolipid metabolism ( p = 2.0 × 10 −122 ) and focal adhesion ( p = 2.9 × 10 −60 ) ( Figure 2 A).

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