Four-factor nomogram for early-onset sepsis in preterm neonates: Development and internal validation of a stewardship tool.

For umbilical cord abnormalities and gestational age, the interaction term was marginally significant (β = 0.24, P = 0.098; AIC = 1177.7), showing a 20% EOS risk increase at 25–28 weeks, which attenuated after 34 weeks ( S4A Fig ).

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Notably, the gestational age × cord abnormality interaction had a P-value of 0.098, suggesting borderline significance, but was retained due to mechanistic plausibility.

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