Higher aged neutrophils and differential inflammatory profiles in sickle cell disease patients on chronic transfusion therapy versus those on hydroxyurea.

Thus, we focused on those two measures to assess if there were any association between treatment and these markers There were no statistically significant differences in the SDI or ratio of F:B in the two treatment groups, although there was a nonsignificant trend towards higher F:B ratio in patients treated with CT (p=0.13, Mann-Whitney) ( Figure 3 ).

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