Hepatic Inflammation and Liver Injury in a Model of Bacterial Infection Triggered Acute-on-Chronic Liver Injury.

J Gastroenterol Hepatol · 2025 · PMC12511834 · PMID 40820372

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We have previously combined the chronic plus binge alcohol feeding model (NIAAA model) [ 11 ] with Abcb4 −/− mice in order to study the inflammatory and immune responses in the alcohol‐triggered ACLI model [ 12 ], where highly significant overexpression of Il‐6 and Mcp‐1 in alcohol‐challenged Abcb4 −/− mice highlighted the importance of the acute insult (alcohol) in pre‐injured liver (knockout mice).

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