Obesity induced by a high-fat diet regulates the MYC‒PPIL1 network in the mediation of asthenozoospermia.

Experimental validation This study validated the relationship between HFD obesity and AZS through animal experiments.Compared to the normal control (NC) group, the high-fat diet (HFD) group showed a decreasing trend in organ weights, though the differences were not statistically significant (HFD group: TW: 1.83 ± 0.22 vs NC group: 1.95 ± 0.26; EW: 0.66 ± 0.05 vs 0.78 ± 0.06; TC: 0.63 ± 0.04 vs 0.75 ± 0.11; EC: 0.21 ± 0.06 vs 0.34 ± 0.04; all indicators P > 0.05; Fig. 5 A).

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