The results showed that the decrease in the abundance of probiotics (e.g., g_Bifidobacterium) showed a highly significant negative correlation with the percentage of liver lipid droplets, and with senescence-related indicators, p21CIP1 and p16INK4a (Fig. 7 A).
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Orally ingested nanosilica causes liver-specific accumulation and induces liver senescence and fibrosis via the microbiota-gut-liver axis.
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