Comparative Effectiveness and Safety of Intravenous Versus Oral Iron Therapy With Iron-Deficient Heart Failure: A Network Meta-Analysis of Randomized Controlled Trials.

Summary of Treatment Rankings and Comparative Efficacy IV iron therapy emerges as the top intervention for most endpoints: Best at replenishing iron stores (ferritin, TSAT), reducing HF hospitalization risk (high-quality evidence), provides clear improvement in exercise capacity (moderate evidence), and may reduce CV mortality slightly (moderate evidence, borderline significance).

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The statistically significant advantage of IV iron over placebo was confirmed in the indirect network contrast, whereas PO iron did not achieve significance against either comparator (Figure 4E ).

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