In our case, the low crystallinity degrees and the amorphous particles presence are probably due to the rapid precipitation, by the physical action of ultrasound applied to the amoxicillin trihydrate particles, leading to more or less significant fragmentation of the particles formed depending on the frequency used.
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The effect of ultrasound on the crystallization-precipitation process of transforming sodium amoxicillin into amoxicillin trihydrate.
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