Yimusake ameliorates corporal endothelial dysfunction by down-regulating the NLRP3 inflammasome-mediated NF-κB signaling pathway and inhibiting oxidative stress.

Conversely, in the Sh-NLRP3, Y and Sh-NLRP3+ Y groups, the expression of NLRP3 and its downstream factors exhibited a decreasing trend ( P < .05), with the Sh-NLRP3 + Y group showing more significant changes ( P < .05), Among them, the expression of NLRP3 and p65 mRNA was reduced in the Sh-NLRP3 + Y group compared with the Sh-NLRP3 and the Y group, but the difference was not statistically significant ( Figure 3A-G ).

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