Construction of a prediction model for hepatocellular carcinoma based on machine learning and its prognostic characteristics.

Figure 10 J–O shows that TP53 expression levels were significantly higher in patients aged > 65 years than in those aged ≤ 65 years ( P = .00065) and higher in men than in women ( P = .0033); in addition, TP53 expression levels were correlated with HCC histologic stages, with significant differences between Stage I and Stage II ( P = .029) and Stage II and Stage III ( P = .011), and Stage II expression levels were higher than those of Stage I and Stage III, and with the progression of staging, TP53 expression showed a decreasing trend; TP53 expression level was also correlated with T stage, and there were significant differences between T1 and T2 ( P = .037) and T2 and T3 ( P = .025), and the expression level of T2 was higher than that of T1 and T3; in addition, TP53 expression was significantly higher in patients without lymph node metastasis (N0) than in N1 ( P = .0099); however, TP53 was not significantly associated with distant metastasis in HCC patients. 3.12.

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