Neuropeptide Y1 receptor expressing circuit from the central amygdala to lateral hypothalamus modulates binge-like ethanol consumption in a sex-dependent manner.

Linear regressions for Y1R mRNA expression and IAE ethanol consumption for FIB‐NPY animals indicate a trend toward significance Week 1 ( F (1, 32) = 3.075, p = 0.089; R 2 = 0.0877), and a significant negative association between Y1R and IAE Week 2 ( F (1, 32) = 5.816, p = 0.0218; R 2 = 0.1538), as well as Week 3 ( F (1, 32) = 5.194, p = 0.0295; R 2 = 0.1396), indicating that higher Y1R mRNA expression significantly predicted lower ethanol intake (Figure 6A ).

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