Ablation of progranulin augments microglial activation and accelerates prion progression.

Acta Neuropathol Commun · 2025 · PMC12519607 · PMID 41084086

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a decreasing trendno p-value reported

Cytokine analysis revealed that TNFα were significantly elevated in Grn -/- mouse brains compared to Grn +/- and Grn +/+ littermates, whereas IL-1β and IL-6 was downregulated or showed a decreasing trend (Fig. 3 e).

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