Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top-Down Middle Cingulate Amygdala Regulation and Brain-Wide Fear Representations.

OT Reduced Subjective Fear Experience in Social Fear Naturalistic Contexts The ANOVA revealed a significant main effect of emotion ( F (1,65) = 1434, p < 0.0001, η p 2 = 0.957, Figure 1 a ) such that participants rated subjective fear considerably higher during fear trials (FS and FNS) than neutral ones, and a significant main effect of social ( F (1,65) = 76.81, p < 0.0001, η p 2 = 0.542, Figure 1a ) reflecting lower fear during social trials (FS and NS) compared with non‐social trials, and a marginally significant main effect of treatment ( F (1,65) = 3.31, p = 0.074, η p 2 = 0.048, Figure 1a ).

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The three‐way interaction effect (treatment × emotion × social) failed to reach significance ( F (1,65) = 0.869, p = 0.355, Figure 1a ).

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