Case Report: Longitudinal mass cytometry profiling of a patient with disseminated histoplasmosis and secondary hemophagocytic lymphohistiocytosis.

Front Immunol · 2025 · PMC12521218 · PMID 41103420

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an increasing trendno p-value reported

Between 2012 and 2022, a total of 225 cases of histoplasmosis were reported in China, with an increasing trend in incidence observed over the past 11 years ( 2 , 3 ).

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a decreasing trendno p-value reported

Notably, the expression levels of pro-inflammatory cytokines TNF-α and IL-17 within NK cells exhibited a decreasing trend, indicating a progressive attenuation of the hyperinflammatory state.

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