Interobserver reproducibility of a hybrid three-tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international Uropathology study.

Histopathology · 2025 · PMC12522021 · PMID 40058790

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Grade is not a significant factor in determining recurrence; however, grade is highly significant in predicting progression (≥T2). 12 , 13 Irrespective of the grading system used, both WHO 2004/2022 and WHO 1973 show differences in progression within the carcinoma categories, with LG progressing less than HG (WHO 2004/2022), while progression rates in G3>G2>G1 using WHO 1973.

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