highly significantP = 1.2 × 10 −53
itive individuals, making them suboptimal controls for this analysis. Fine mapping of the LYZ eQTL effect of the resistance-associated variants The resistance-associated variants of the 12q15 locus are in strong linkage disequilibrium ( r 2 > 0.8) and were included in the analysis because of their highly significant eQTL effect on the LYZ gene in whole blood (e.g., rs622656 eQTL normalized effect size (NES) = − 0.55; P = 1.2 × 10 −53 ) and the lung (rs622656 eQTL NES = − 0.35; P = 4.7 × 10 −21 ) in GTEx v8.