Enhanced Collagen Prolyl 4-Hydroxylase Activity and Expression Promote Cancer Progression via Both Canonical and Non-Canonical Mechanisms.

Crystallization of the P4HA2 structure shows rearrangements of other conserved residues, for example, Tyr196 and Arg223, which may be significant enough to cause differences in contacts in the crystal structure, possibly explaining other differences in substrate binding affinities as described above [ 17 ].

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