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Trends in the Burden of Headache Disorders in Europe, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021.

J Clin Med · 2025 · PMC12525519 · PMID 41096046

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an increasing trendno p-value reported
The headache burden among pediatric and adolescent patients is also significant and shows an increasing trend [ 14 , 15 , 16 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.