In female mice, we found an increasing trend in CYP1A1 protein levels with APOE4 status and exposure to PS-NMPs ( figures 6(E) – (G) .
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Short-term exposure to polystyrene microplastics alters cognition, immune, and metabolic markers in an apolipoprotein E (APOE) genotype and sex-dependent manner.
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In female mice, we observed mild increases in CYP1A1 mRNA expression following exposure to PS-NMPs ( figure 6(H) ); however, we observed a decreasing trend in CYP1A1 mRNA expression with APOE4 status and exposure to PS-MPs in male mice ( figure 6(D) ).