Thymic epithelial cells amplify epigenetic noise to promote immune tolerance.

To investigate how p53 is repressed in mTECs, we assessed the differential expression of known p53 regulators and found highly significant induction of Mdm2 (the primary regulator of p53 that promotes its proteosomal degradation 18 ) during mTEC maturation at both the transcript and protein levels (Fig. 2l and Extended Data Fig. 3d–g ).

also in 132,142 other papers