Integrative multidimensional analysis of age-associated synthetic lethal genes and development of a prognostic model in breast cancer.

Expression profiling revealed that SLC7A5 was significantly differentially expressed across cell types, particularly between epithelial cells and fibroblasts, mast cells, plasma cells, and T cells, with highly significant differences (p < 0.0001), suggesting cell type–specific functional roles ( Figure 6G ). 3.7 Mechanistic insights into the role of SLC7A5 in BRCA Gene set enrichment analysis (GSEA) revealed that low-SLC7A5–expressing samples exhibited downregulation of pathways related to immune responses, cell adhesion, and proliferation, including allograft rejection, cell adhesion molecules, cell cycle, and cytokine–cytokine receptor interaction ( Figures 7A, C ).

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Both simple and weighted mode approaches yielded consistent effect directions with marginal significance, reinforcing the role of SLC7A5 in ER-negative BRCA.

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