Integrating necroptosis and immune landscapes: a multi-omics-derived NecropImmScore stratifies prognosis and therapy in ovarian cancer.

Cancer Immunol Immunother · 2025 · PMC12528613 · PMID 41094064

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 2.22e-16actually significant

Notably, the NecropImmScore strongly correlated with immunophenotype score (IPS), with high-score tumors exhibiting significantly higher IPS across all combinations of CTLA-4 and PD-1/PD-L1 status (all p -values highly significant, e.g., p < 2.22e-16, F i g. 6 F–I), indicating enhanced potential response to immune checkpoint blockade.

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