Locally advanced non-small cell lung cancer with negative or low programmed death ligand 1 expression: a prognostic factor analysis of real-world data after the PACIFIC trial.

Multivariate analyses revealed that interstitial lung abnormality (ILA) score ≥ 1 was a significant factor of shorter OS and higher CI-IFR, and a mean heart dose ≥ 7.5 Gy showed a trend toward significance for shorter OS., Internal high-dose volumetric modulated arc therapy was associated with lower CI-R, whereas poor baseline performance status correlated with higher CI-DM.

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