Barely Significant
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Efficacy and Safety of Zilebesiran for the Management of Hypertension: An Updated Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Cureus · 2025 · PMC12530167 · PMID 41111811

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hedged sentence
0.0000
closest p · 0.0× alpha
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boldest claim

The sentences

highly significantp-value <0.00001actually significant
The overall pooled analysis demonstrated a highly significant effect, indicating strong evidence for a reduction in 24-hour ambulatory SBP (Z=15.33; p-value <0.00001).

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