Switching from febuxostat to dotinurad, a novel selective urate reabsorption inhibitor, may substantially reduce serum urate levels, through URAT1 inhibition, potentially without adversely affecting ABCG2 function: findings from the SWITCH SURI study.

Front Endocrinol (Lausanne) · 2025 · PMC12530334 · PMID 41113711

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a decreasing trendp < 0.01actually significant

In this subgroup, mean plasma indoxyl sulfate concentrations demonstrated a decreasing trend from the baseline value of 2.5 ± 0.7 μg/mL, with values of 2.1 ± 0.9 μg/mL at week 4 (p < 0.01), 2.1 ± 1.3 μg/mL at week 12 (p = 0.07), and 2.0 ± 1.1 μg/mL at week 24 (p < 0.05).

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