Assessment of genetic and metabolite associations of branched chain amino acids with metabolic disease in the UK Biobank using Mendelian randomization.

BMC Med Genomics · 2025 · PMC12532399 · PMID 41102794

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Conclusions Our study identifies over 50 highly significant disease associations with the branched-chain amino acids leucine, isoleucine, and valine and further explores the relationships of BCAAs with type II diabetes, obesity, hypertension, sleep apnea, and chronic kidney disease.

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