Functional Determinants and Evolutionary Consequences of Pleiotropy in Complex and Mendelian Traits.

When genes were split into categories according to their pLI value, highly pleiotropic genes showed a universal and highly significant enrichment with LoF-intolerant (pLI > 0.9) genes across all data sources (30%, 31%, 27%, and 24% of highly pleiotropic genes were LoF intolerant compared to 14%, 13%, 20%, and 20% of nonpleiotropic ST genes for HPO, MGD, pan-UKB, and FinnGen data, respectively; P << 0.001 in chi-squared test in all cases).

also in 132,142 other papers