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Temporal Trends and Regional Disparities in Knee Osteoarthritis Across the United Kingdom: Insights From the Global Burden of Disease Study 1990-2021.

Cureus · 2025 · PMC12535415 · PMID 41111710

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a decreasing trendno p-value reported
an increasing trendno p-value reported
A positive APC or AAPC with a lower CI bound above zero indicates an increasing trend, while a negative APC or AAPC with an upper CI bound below zero shows a decreasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.