Single-cell atlas of the esophageal squamous cell carcinoma immune ecosystem to predict immunotherapy response.

Signal Transduct Target Ther · 2025 · PMC12536040 · PMID 41111072

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a favorable trendno p-value reported

Our ECGEA cohort of ESCC patients receiving anti–PD-1 monotherapy demonstrated that high ENTPD1 (CD39) expression was associated with improved clinical outcomes (log rank P = 1.5 × 10 − 11 ), with a Cox HR of 0.35 (95% CI 0.09–1.31), indicating a favorable trend with imprecise effect (Fig. 5i ).

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