marginal significancep = 0.052
36 showed that patients treated with intensive local therapy (defined as en bloc resection, curettage, or RT with BED > 85 Gy) demonstrated significantly better OS ( p = 0.006) for those with solitary bone metastasis, but only marginal significance ( p = 0.052) for those with multiple bone metastases, when compared to those treated with less intensive (RT with BED < 85 Gy) or no therapy.