Causal effects of immune cells on the efficacy and adverse drug reactions of platinum drugs.

The protective factors for renal injury exhibit five extremely significant immune cell traits ( P < 0.01), namely central memory CD4 – CD8 – T cell % T cell (OR = 0.007, P = 7.83 × 10 –4 ), CD8 on central memory CD8 + T cell (OR = 0.116, P = 0.003), BAFF-R on IgD – CD38 + B cell (OR = 0.086, P = 0.006), CD4 – CD8 – NK T cell % T cell (OR = 0.068, P = 0.007), and CD25 ++ CD45RA – CD4 + non-regulatory T cell (non-Treg) absolute count (OR = 0.041, P = 0.007).

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