Long-term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish.

Interestingly, however, even after a 5 month period of depuration, there was still a highly significant ( F = 12.81 p = 0.003) impact of exposure on fertilization success; the proportion of nonviable eggs at 14 hpf increased to 16.2% in 0.5 ng/L EE 2 and 24% in 5 ng/L EE 2 compared with a rate of 7.8% in the controls.

also in 132,142 other papers