Barely Significant
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Global, regional, and national burdens of lower extremity peripheral arterial disease from 1990 to 2021 and projections to 2050: global burden of disease study 2021.

Front Cardiovasc Med · 2025 · PMC12537751 · PMID 41126923

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hedged sentences
0.0010
closest p · 0.0× alpha
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boldest claim

The sentences

a decreasing trendP < 0.001actually significant
Analysis of temporal connectivity points From 1990 to 2021, the global ASIR for LEPAD showed a decreasing trend ( Figure 6A ), with AAPC of −0.40% (95% CI of −0.42, −0.38, P < 0.001) for ASIR and −1.46% (95% CI of, P < 0.001) for ASMR ( Supplementary Table S4 ).

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an increasing trendno p-value reported
Interestingly, ASIR decreased in both the high and medium-high SDI regions between 1990 and 2021, with the most significant decrease in the high SDI region whereas ASIR in the low, medium-low, and medium SDI regions showed an increasing trend.

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