a decreasing trendP < 0.001
Analysis of temporal connectivity points From 1990 to 2021, the global ASIR for LEPAD showed a decreasing trend ( Figure 6A ), with AAPC of −0.40% (95% CI of −0.42, −0.38, P < 0.001) for ASIR and −1.46% (95% CI of, P < 0.001) for ASMR ( Supplementary Table S4 ).