Single-cell multiome characterizing intercellular communication and intracellular regulation of epithelium and mesenchymal during secondary palate development in mice.

Comput Struct Biotechnol J · 2025 · PMC12538024 · PMID 41127818

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The BMP pathway as a principal signaling mechanism in epithelial cells at E12.5 CellChat analysis identified a highly significant BMP signaling subnetwork, highlighting the pivotal role of epithelial cells in initiating ligand signaling to mesenchymal subpopulations, particularly at E12.5, with a subsequent decline by E14.5 ( Fig. 4 A).

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